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Fight negative effects of chronic stress and aging

​Stay CALM. Stay SHARP. Stay STRONG.

why use

Stay CALM.

Balancing stress is key to living your best. Under stress, your body makes a hormone called cortisol, which can be helpful in order to deal the stress. But when chronic stress produces too much cortisol for too long, harmful effects can result:

  • mood disorders

  • heart disease

  • headaches

  • weight gain

  • etc.

No matter the cause, chronic stress can have negative effects, both mental and physical.
HT-PS23 can help.​​

In a clinical trial, a group of stressed nurses were given either a placebo or HT-PS23 each day for 8 weeks. Those who took HT-PS23 showed significant benefits:

reduced cortisol levels

 At the beginning of the trial, blood cortisol levels were similar between the placebo and treatment groups. Cortisol was significantly lower in those taking HT-PS23 after 8 weeks.

VB Cortisol Overall_edited.png

 Participants who reported being the most anxious or stressed at the beginning of the trial showed especially decreased cortisol levels after taking HT-PS23.

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lower anxiety
more job satisfaction

 Taking HT-PS23 reduced state anxiety (specific-situation emotional reaction) levels versus placebo.

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 Those taking HT-PS23 reported increased job satisfaction compared to those taking a placebo.

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Few things are more important than brain health. After all, your nervous system controls your entire body, and your mind is what makes you you.

Slow, persistent stress accumulates as we age. As time goes on, this chronic damage can impair brain function. HT-PS23 have been shown to benefit and even reverse many of these signs of neural stress and aging.

In preclinical studies (here, here, and here), the following benefits were seen in aged or stressed mice that were given HT-PS23:

Mice were trained in a water maze to test their learning and memory. Their target was located in the upper right quadrant (outlined in red) in the images below.

 When tested, the aged mice given HT-PS23 performed as well as the non-aged group (Non-aging), spending significantly more time in the target area, suggesting they learned and remembered better, than the control aged group (Aging).

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increased serotonin

The neurotransmitter serotonin not only helps to balance mood but also to boost cognition. Recent studies (here, here, and here) describe specific roles that serotonin plays in learning and memory.


Serotonin levels were tested in the mice at the end of the study.

✓ Aged mice who received HT-PS23 had much higher levels of serotonin in their hippocampi (brain area highly involved in learning and memory).

VB serotonin hipp_edited.png


less inflammation

Inflammation is necessary for a healthy immune system. But just as with stress, too much for too long can cause a range of chronic symptoms, including impaired cognitive function. This damage may be caused by systemic disease or may simply be a natural result of aging. Reducing inflammation can prevent or even reverse negative symptoms.


After treatment, the mice's inflammation markers were analyzed.

After taking HT-PS23, there was a significant reduction of inflammatory IL-6. (Read about IL-6 here.)

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 Significant increase of anti-inflammatory IL-10 resulted after taking HT-PS23. (Read about IL-10 here and here.)

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more BDNF

Another key component for a healthy brain is brain-derived neurotrophic factor, simply known as BDNF (explained in great detail here). This molecule helps your neurons grow and change, enabling you to learn and acquire memories. Reduced amounts of BDNF can result from neurological and psychiatric diseases, after periods of chronic stress, or simply due to natural aging.

BDNF in the mice was measured post-treatment.

Average levels of BDNF nearly doubled after stressed mice were given HT-PS23, compared to the non-treated stressed group.

VB BDNF_edited.png


Loss of muscle tissue that naturally happens with aging. It begins gradually in most people around age 30, and muscles continue this functional decline (atrophy) throughout life. Conditions such as certain diseases or muscle inactivity can accelerate this atrophy, leading to symptoms that include:

  • weakness and frailty

  • balance problems/falling

  • impaired movement

  • fatigue and depression

Because of the neural and hormonal connections between muscle tissue, the nervous system, and the GI tract, it makes sense that your gut microbiome affects muscle function. In fact, atrophy in aging muscle has been observed to be improved by taking HT-PS23.

Preclinical results (here) show aged mice benefitted in the following ways after being given HT-PS23:

✓ Muscle fiber area increased more than 50% after taking HT-PS23, compared to reduced fiber mass in aging mice.

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GAS Muscle_edited.jpg

GAS: gastrocnemius, TA: tibialis anterior, CSA: cross-sectional area. ***p < 0.001 compared with non-aging group. ###p < 0.001 compared with aging group.

The group given HT-PS23 had an average grip strength that was 50% stronger than the aged mice.

Grip Strength_edited.jpg

**p < 0.05, *p < 0.01 compared with non-aging group. ###p < 0.001 compared with aging group.

Muscle growth and atrophy are controlled by multiple complex mechanisms in your body. There are many molecules involved at any given time, each affecting muscle in a unique way. Growth hormone plays a central role in muscle building. Growth hormone is stimulated by a number of factors, including the "hunger hormone" ghrelin. In turn, growth hormone then triggers several other molecules that promote muscle growth. Among these is an enzyme called Akt, which helps muscle cells differentiate, grow, and recover if damaged.

At the end of the study, levels of Akt and ghrelin were measured.

In aged mice given HT-PS23, levels of both Akt and ghrelin were restored to amounts similar to those found in non-aging mice, and significantly higher than in the aged, non-treated group.

VB Ghrelin_edited.png
VB p-akt_edited.png

*p < 0.05, **p < 0.01 compared with non-aging group. #p < 0.05 compared with aging group.

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